检索范围:
排序: 展示方式:
Prevalence of antifolate drug resistance markers in in China
《医学前沿(英文)》 2022年 第16卷 第1期 页码 83-92 doi: 10.1007/s11684-021-0894-x
关键词: drug resistance antifolates molecular markers Plasmodium vivax China
Molecular markers and pathogenically targeted therapy in non-small cell lung cancer
Bo PENG BA , Jinnong ZHANG MD , Jamile S. WOODS MD , Wei PENG MD, PhD
《医学前沿(英文)》 2009年 第3卷 第3期 页码 245-255 doi: 10.1007/s11684-009-0044-3
关键词: lung cancer carcinoma non-small cell lung cancer molecular markers targeted therapy
Molecular alterations and clinical relevance in esophageal squamous cell carcinoma
null
《医学前沿(英文)》 2013年 第7卷 第4期 页码 401-410 doi: 10.1007/s11684-013-0286-y
Esophageal squamous cell carcinoma (ESCC) is one of the most common types of gastrointestinal cancers, and the fourth leading cause of cancer-related deaths in China. Early detection and intervention in time may dramatically increase the survival of the patients by initiating treatment regimens during earlier stages of ESCC or even during precancerous stages. Molecular classification will be useful for subtyping esophageal tumors or precancerous lesions to improve current therapeutics or early intervention of the disease. In this review, we summarize the findings in investigating the molecular alterations and clinical relevance of ESCC.
关键词: esophageal squamous cell carcinoma (ESCC) early detection molecular classification molecular markers
Identification of molecular markers linked to rice bacterial blight resistance genes from
Jing WANG,Chen CHENG,Yanru ZHOU,Yong YANG,Qiong MEI,Junmin LI,Ye CHENG,Chengqi YAN,Jianping CHEN
《农业科学与工程前沿(英文)》 2015年 第2卷 第3期 页码 260-265 doi: 10.15302/J-FASE-2015070
关键词: Oryza meyeriana bacterial blight resistance gene genetic population linkage molecular marker
Wheat research and breeding in the new era of a high-quality reference genome
Rudi APPELS
《农业科学与工程前沿(英文)》 2019年 第6卷 第3期 页码 225-232 doi: 10.15302/J-FASE-2019265
The publications of the International Wheat Genome Sequencing Consortium (IWGSC) released in August 2018 are reviewed and placed into the context of developments arising from the availability of the high-quality wheat genome assembly.
关键词: assembly technology molecular markers polyploidy transcript networks wheat genome
Genetic and clinical markers for predicting treatment responsiveness in rheumatoid arthritis
Xin Wu, Xiaobao Sheng, Rong Sheng, Hongjuan Lu, Huji Xu
《医学前沿(英文)》 2019年 第13卷 第4期 页码 411-419 doi: 10.1007/s11684-018-0659-3
The value of epigenetic markers in esophageal cancer
Xiao-Mei ZHANG, Ming-Zhou GUO,
《医学前沿(英文)》 2010年 第4卷 第4期 页码 378-384 doi: 10.1007/s11684-010-0230-3
关键词: epigenetics DNA methylation esophageal cancer dysplasia
Exploring the diagnosis markers for gallbladder cancer based on clinical data
null
《医学前沿(英文)》 2015年 第9卷 第3期 页码 350-355 doi: 10.1007/s11684-015-0402-2
Presently, no effective markers are available to facilitate gallbladder cancer (GBC) diagnosis. This study aims to explore available markers for GBC diagnosis. Clinical data of 144 GBC and 116 cholelithiasis patients were retrospectively reviewed. Logistic regression analysis was performed to evaluate GBC risk factors. A receiver operating characteristic (ROC) curve was used to assess the diagnosis value of the risk factors. By comparing the characteristic of GBC and cholelithiasis patients, the following factors exhibited statistical difference: age, gender, gallstones, total bilirubin (TB), alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), platelet count (PLT), CA125 (carcinoembryonic antigen 125), and CA199 (carbohydrate antigen 199). Logistic regression analysis indicated that age [odds ratio (OR), 1.032; 95% confidence interval (95% CI), 1.004 to 1.061; P = 0.024], gender (OR, 0.346; 95% CI, 0.167 to 0.716; P = 0.004), gallstones (OR, 0.027; 95% CI, 0.007 to 0.095; P<0.001), ALP (OR, 1.003; 95% CI, 1.000 to 1.006; P = 0.032), TB (OR, 1.004; 95% CI, 1.000 to 1.009; P = 0.042), and CA125 (OR, 1.007; 95% CI, 1.002 to 1.013; P = 0.011) were independent risk factors for GBC. According to the ROC curve, CA125 [area under curve (AUC), 0.720], ALP (AUC, 0.713), TB (AUC, 0.636), and age (AUC, 0.573) were valuable diagnosis markers. Additionally, based on the independent risk factors, the GBC diagnosis model was established. Age, TB, ALP, and CA125 can be used as auxiliary diagnosis factors of GBC. The diagnosis model provides a quantitative tool for GBC diagnosis when comprehensively considering various risk factors.
Effect of renal function and hemodialysis on the serum tumor markers in patients with chronic kidney
YU Xiaofang, XU Xialian, YE Zhibin
《医学前沿(英文)》 2007年 第1卷 第3期 页码 308-311 doi: 10.1007/s11684-007-0059-6
Clinical study on the related markers of blood coagulation in the patients with ANFH after SARS
WU Lianhua, GAO Chunjin, WANG Guozhong, YANG Lin, HOU Xiaomin, GE Huan, XIA Chengqing, QI Man
《医学前沿(英文)》 2007年 第1卷 第4期 页码 410-412 doi: 10.1007/s11684-007-0080-9
关键词: significant difference partial thromboplastin coagulation function femoral healthy
Special issue on “Molecular Sensors and Molecular Logic Gates”
Luling Wu , Tony D. James
《化学科学与工程前沿(英文)》 2022年 第16卷 第1期 页码 1-3 doi: 10.1007/s11705-021-2134-y
《化学科学与工程前沿(英文)》 2022年 第16卷 第2期 页码 168-182 doi: 10.1007/s11705-021-2056-8
关键词: computer-aided molecular design bio-oil additives molecular signature descriptor
Progress on molecular biomarkers and classification of malignant gliomas
null
《医学前沿(英文)》 2013年 第7卷 第2期 页码 150-156 doi: 10.1007/s11684-013-0267-1
Gliomas are the most common primary intracranial tumors in adults. Anaplastic gliomas (WHO grade III) and glioblastomas (WHO grade IV) represent the major groups of malignant gliomas in the brain. Several diagnostic, predictive, and prognostic biomarkers for malignant gliomas have been reported over the last few decades, and these markers have made great contributions to the accuracy of diagnosis, therapeutic decision making, and prognosis of patients. However, heterogeneity in patient outcomes may still be observed, which highlights the insufficiency of a classification system based purely on histopathology. Great efforts have been made to incorporate new information about the molecular landscape of gliomas into novel classifications that may potentially guide treatment. In this review, we summarize three distinctive biomarkers, three most commonly altered pathways, and three classifications based on microarray data in malignant gliomas.
关键词: malignant glioma molecular biomarker IDH1 MGMT molecular classification
Molecular classification and molecular targeted therapy of cancer
null
《医学前沿(英文)》 2013年 第7卷 第2期 页码 147-149 doi: 10.1007/s11684-013-0274-2
分子电子学的发展 Review
Paven Thomas Mathew, 房丰洲
《工程(英文)》 2018年 第4卷 第6期 页码 760-771 doi: 10.1016/j.eng.2018.11.001
分子电子学(moletronics)是用分子作为单元对分子电子学器件进行装配。这是一个包含物理、化学、材料科学及工程等学科的多学科交叉领域。分子电子学致力于使硅元件尺寸进一步减小。科学家已经在等效分子器件方面进行了诸多探索性研究。分子电子学在电子以及光子应用中逐渐产生影响,如导电聚合物、光色材料、有机超导体、电致变色材料等。为了满足减小硅片尺寸的需求,研究人员有必要将这种新型技术引入到分子层面。虽然分子层面仪器的实验验证和建模分析是一项艰巨的任务,但分子电子学领域依然出现了突破性进展。本文将对不同分子器件和潜在的适用于不同器件的分子应用结合起来进行讨论,如分子晶体管、分子二极管、分子电容、分子导线和分子绝缘体等。本文简要讨论未来的发展趋势以及介绍各种基于石墨烯已取得一定研究成果的分子仪器。
标题 作者 时间 类型 操作
Molecular markers and pathogenically targeted therapy in non-small cell lung cancer
Bo PENG BA , Jinnong ZHANG MD , Jamile S. WOODS MD , Wei PENG MD, PhD
期刊论文
Identification of molecular markers linked to rice bacterial blight resistance genes from
Jing WANG,Chen CHENG,Yanru ZHOU,Yong YANG,Qiong MEI,Junmin LI,Ye CHENG,Chengqi YAN,Jianping CHEN
期刊论文
Genetic and clinical markers for predicting treatment responsiveness in rheumatoid arthritis
Xin Wu, Xiaobao Sheng, Rong Sheng, Hongjuan Lu, Huji Xu
期刊论文
Effect of renal function and hemodialysis on the serum tumor markers in patients with chronic kidney
YU Xiaofang, XU Xialian, YE Zhibin
期刊论文
Clinical study on the related markers of blood coagulation in the patients with ANFH after SARS
WU Lianhua, GAO Chunjin, WANG Guozhong, YANG Lin, HOU Xiaomin, GE Huan, XIA Chengqing, QI Man
期刊论文
Design of bio-oil additives via molecular signature descriptors using a multi-stage computer-aided molecular
期刊论文